Rapidone Uses, Dosage, Side Effects, FAQ - MedicinesFAQ (2023)

Rapidone Suspension, Tablet

Rapidone is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.

Rapidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.

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Stimulation of gut motility in-

  • Non-ulcer dyspepsia
  • Oesophageal reflux, reflux oesophagitis and gastritis
  • Diabetic gastroparesis
  • Functional dyspepsia
  • Speeding barium transit in follow through radiological studies

Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.

In the prophylactic treatment of migraine.

Rapidone is also used to associated treatment for these conditions: Diabetic Gastroparesis, Dyspepsia, Erosive Esophagitis, Gastrointestinal Symptoms, Non-erosive Reflux Esophagitis Disease (NERD), Upper gastrointestinal motility disorders

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How Rapidone works

Rapidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Rapidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting


Trade Name Rapidone
Generic Domperidone
Domperidone Other Names Domperidona, Domperidone, Domperidonum
Weight 1mg/ml, 10mg
Type Suspension, Tablet
Formula C22H24ClN5O2
Weight Average: 425.911
Monoisotopic: 425.161852744
Protein binding


Groups Approved, Investigational, Vet approved
Therapeutic Class Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs
Manufacturer Zinta Pharmaceuticals Industries
Available Country Pakistan
Last Updated: June 7, 2022 at 8:54 pm


Rapidone Uses, Dosage, Side Effects, FAQ - MedicinesFAQ (1)

Table Of contents

  • Rapidone
  • Uses
  • Dosage
  • Side Effect
  • Precautions
  • Interactions
  • Uses during Pregnancy
  • Uses during Breastfeeding
  • Accute Overdose
  • Food Interaction
  • Half Life
  • Volume of Distribution
  • Clearance
  • Interaction With other Medicine
  • Contradiction
  • Storage

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Rapidone dosage

Adults: 10 - 20 mg every 4 - 8 hours daily

Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.

Rapidone tablet and suspension should be taken 15 - 30 minutes before a meal. For acute nausea and vomiting, maximum period of treatment is 12 weeks.

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Side Effects

Rapidone may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.


Side effects include galactorrhea, gynecomastia, or menstrual irregularities.

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Rapidone should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.


Rapidone may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Rapidone on gastrointestinal function.

Food Interaction

  • Take before a meal. Take 15-30 minutes before meals.

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Half Life

7 hours

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Pregnancy & Breastfeeding use

Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.

Use in lactation: Rapidone may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.

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Rapidoneis contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.

Acute Overdose

Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.

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Storage Condition

Store in a cool dry place protected from light. Keep out of reach of children.

Innovators Monograph

You find simplified version here Rapidone

Rapidone contains Domperidone see full prescribing information from innovator Rapidone Monograph, Rapidone MSDS, Rapidone FDA label


What is Rapidone used for?

Rapidone help to stop feeling or being sick like as nausea or vomiting.It can also be used to treat stomach pain if you're having end of life care. Rapidone is sometimes used to increase milk supply.

Is Rapidone safe to take?

For most people, taking Rapidone is safe.If you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate.

What are the side effects of Rapidone?

Common side effects of Rapidone are include:

  • swelling of the ankles/feet.
  • unusual tiredness.
  • mental/mood changes (e.g., nervousness, irritability)
  • hot flashes.
  • breast swelling/pain.
  • unusual leakage of milk from the breast.
  • changes in menstrual periods.
  • decreased sexual ability.

Is Rapidonesafe during pregnancy?

Rapidone is not usually recommended in pregnancy.

Why Rapidone is not safe in pregnancy?

Rapidone is contraindicated for use in pregnant women and in women suspected of being pregnant, due to teratogenicity observed in reproductive toxicity studies.

Is Rapidone safe during breastfeeding?

A very small amount of the Rapidone you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking Rapidone.

Can I drink alcohol with Rapidone?

It is best to avoid alcohol when taking Rapidone. Drinking alcohol can make side effects worse, such as sleepiness or an irregular heartbeat.

How long does Rapidone take to work?

Rapidone often takes at least three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer.

Can I take Rapidone before bed?

Rapidone is best taken 15 to 30 minutes before meals and id necessary at bedtime.

Is Rapidone good for acid reflux?

It decreases postprandial reflux time and is therefore used to treat regurgitation and vomiting.

Can I take Rapidone after eating?

Rapidone is best taken about 15 to 30 minutes before meals, with a glass of water. If you take Rapidone after a meal, it will still work, but it may take longer to have an effect.

Is Rapidone good for gastritis?

Rapidone has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment.Rapidone is a kind of drug to strengthen gastric motility.

What does Rapidone do to your body?

Rapidone is a medicine that increases the movements or contractions of the stomach and bowel. Rapidone is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.

Is Rapidone safe for kidneys?

Rapidone are not significantly renally cleared and can be used in CKD.

Does Rapidone help anxiety?

Rapidone is used to treat severe anxiety like as emotional state where you may sweat, tremble, feel anxious and have a fast heartbeat or agitation.

Does Rapidone raise blood pressure?

Rapidone increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.

Is Rapidone a narcotic?

Rapidone is not a controlled substance e.g. sleeping pills, valium, narcotics.

Does Rapidone cause depression?

Rapidone can cause central nervous system side effects such as fatigue, irritability, or depression.

Can I take Rapidone for a long time?

You should usually take Rapidone for up to a week.Because Rapidone can cause an irregular heartbeat if you take it for longer or at a high dose.

What happens when I stop taking Rapidone?

Most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother's milk supply to adjust without frustrating the baby or causing her discomfort. It is very important to stop the Rapidone slowly.

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